Taking aim at rare cancer variants
With a systematic look at function, Broad’s Target Accelerator effort proves that even rare mutations can drive cancer
View ArticleBetter off without it: Broken gene may help protect against ulcerative colitis
Loss-of-function mutation that protects against ulcerative colitis suggests possible therapeutic targets
View ArticleLargest collection of human exome sequence data yields unprecedented tool for...
Deep genetic catalog powers studies of disease and DNA variation
View ArticleChemistry-based approach reveals new target in fight against malaria
Systematic screening identified potential antimalarials with new mechanism of action
View ArticleUnraveling tangled transcriptional webs reveals a dysfunction program in T cells
By identifying a unique gene signature for T cell dysfunction, Broad researchers have uncovered a potential path to help the immune system get back in the game against cancer.
View ArticleReading the rules of gene regulation with CRISPR
We have barely begun to crack open the rulebook for the vast noncoding regions of the genome. Two new methods, building on CRISPR advances, may help reveal some of the pages.
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